Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.
Identifieur interne : 000811 ( Main/Exploration ); précédent : 000810; suivant : 000812Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.
Auteurs : Arnaldo Prata-Barbosa [Brésil] ; Fernanda Lima-Setta [Brésil] ; Gustavo Rodrigues Dos Santos [Brésil] ; Vanessa Soares Lanziotti [Brésil] ; Roberta Esteves Vieira De Castro [Brésil] ; Daniela Carla De Souza [Brésil] ; Carlos Eduardo Raymundo [Brésil] ; Felipe Rezende Caino De Oliveira [Brésil] ; Lucio Flavio Peixoto De Lima [Brésil] ; Cristian Tedesco Tonial [Brésil] ; José Colleti [Brésil] ; Ana Paula Novaes Bellinat [Brésil] ; Vivian Botelho Lorenzo [Brésil] ; Raquel De Seixas Zeitel [Brésil] ; Lucas Pulcheri [Brésil] ; Fernanda Ciuffo Monte Da Costa [Brésil] ; Fabíola Peixoto Ferreira La Torre [Brésil] ; Elaine Augusta Das Neves Figueiredo [Brésil] ; Thiago Peres Da Silva [Brésil] ; Paula Marins Riveiro [Brésil] ; Isabele Coelho Fonseca Da Mota [Brésil] ; Igor Bromonschenkel Brandão [Brésil] ; Zina Maria Almeida De Azevedo [Brésil] ; Simone Camera Gregory [Brésil] ; Fernanda Raquel Oliveira Boedo [Brésil] ; Rosana Novais De Carvalho [Brésil] ; Natália Almeida De Arnaldo Silva Rodriguez Castro [Brésil] ; Daniel Hilário Santos Genu [Brésil] ; Flavia Andrea Krepel Foronda [Brésil] ; Antonio José Ledo A. Cunha [Brésil] ; Maria Clara De Magalhães-Barbosa [Brésil]Source :
- Jornal de pediatria [ 1678-4782 ]
Descripteurs français
- KwdFr :
- Adolescent (MeSH), Betacoronavirus (MeSH), Brésil (MeSH), Durée du séjour (statistiques et données numériques), Enfant (MeSH), Enfant d'âge préscolaire (MeSH), Femelle (MeSH), Hospitalisation (MeSH), Humains (MeSH), Infections à coronavirus (thérapie), Infections à coronavirus (épidémiologie), Mâle (MeSH), Nourrisson (MeSH), Nouveau-né (MeSH), Pandémies (MeSH), Pneumopathie virale (thérapie), Pneumopathie virale (épidémiologie), Syndrome de réponse inflammatoire généralisée (MeSH), Unités de soins intensifs pédiatriques (statistiques et données numériques), Ventilation artificielle (méthodes), Ventilation artificielle (statistiques et données numériques), Études prospectives (MeSH).
- MESH :
- méthodes : Ventilation artificielle.
- statistiques et données numériques : Durée du séjour, Unités de soins intensifs pédiatriques, Ventilation artificielle.
- thérapie : Infections à coronavirus, Pneumopathie virale.
- épidémiologie : Infections à coronavirus, Pneumopathie virale.
- Adolescent, Betacoronavirus, Brésil, Enfant, Enfant d'âge préscolaire, Femelle, Hospitalisation, Humains, Mâle, Nourrisson, Nouveau-né, Pandémies, Syndrome de réponse inflammatoire généralisée, Études prospectives.
- Wicri :
- geographic : Brésil.
English descriptors
- KwdEn :
- Adolescent (MeSH), Betacoronavirus (MeSH), Brazil (MeSH), COVID-19 (MeSH), Child (MeSH), Child, Preschool (MeSH), Coronavirus Infections (epidemiology), Coronavirus Infections (therapy), Female (MeSH), Hospitalization (MeSH), Humans (MeSH), Infant (MeSH), Infant, Newborn (MeSH), Intensive Care Units, Pediatric (statistics & numerical data), Length of Stay (statistics & numerical data), Male (MeSH), Pandemics (MeSH), Pneumonia, Viral (epidemiology), Pneumonia, Viral (therapy), Prospective Studies (MeSH), Respiration, Artificial (methods), Respiration, Artificial (statistics & numerical data), SARS-CoV-2 (MeSH), Systemic Inflammatory Response Syndrome (MeSH).
- MESH :
- geographic : Brazil.
- epidemiology : Coronavirus Infections, Pneumonia, Viral.
- methods : Respiration, Artificial.
- statistics & numerical data : Intensive Care Units, Pediatric, Length of Stay, Respiration, Artificial.
- therapy : Coronavirus Infections, Pneumonia, Viral.
- Adolescent, Betacoronavirus, COVID-19, Child, Child, Preschool, Female, Hospitalization, Humans, Infant, Infant, Newborn, Male, Pandemics, Prospective Studies, SARS-CoV-2, Systemic Inflammatory Response Syndrome.
Abstract
OBJECTIVE
To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19.
METHOD
Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity.
RESULTS
Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43-21.12; p = 0.01).
CONCLUSIONS
In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.
DOI: 10.1016/j.jped.2020.07.002
PubMed: 32781034
PubMed Central: PMC7402103
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Caxias D'Or, Duque de Caxias, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Mota, Isabele Coelho Fonseca Da" sort="Mota, Isabele Coelho Fonseca Da" uniqKey="Mota I" first="Isabele Coelho Fonseca Da" last="Mota">Isabele Coelho Fonseca Da Mota</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Jutta Batista, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Jutta Batista, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Brandao, Igor Bromonschenkel" sort="Brandao, Igor Bromonschenkel" uniqKey="Brandao I" first="Igor Bromonschenkel" last="Brandão">Igor Bromonschenkel Brandão</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Niteroi D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Niteroi D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Azevedo, Zina Maria Almeida" sort="De Azevedo, Zina Maria Almeida" uniqKey="De Azevedo Z" first="Zina Maria Almeida" last="De Azevedo">Zina Maria Almeida De Azevedo</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Gregory, Simone Camera" sort="Gregory, Simone Camera" uniqKey="Gregory S" first="Simone Camera" last="Gregory">Simone Camera Gregory</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Estadual da Criança, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Estadual da Criança, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Boedo, Fernanda Raquel Oliveira" sort="Boedo, Fernanda Raquel Oliveira" uniqKey="Boedo F" first="Fernanda Raquel Oliveira" last="Boedo">Fernanda Raquel Oliveira Boedo</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Norte D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Norte D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Carvalho, Rosana Novais" sort="De Carvalho, Rosana Novais" uniqKey="De Carvalho R" first="Rosana Novais" last="De Carvalho">Rosana Novais De Carvalho</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Santa Izabel, Santa Casa da Misericórdia, Salvador, BA, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Santa Izabel, Santa Casa da Misericórdia, Salvador, BA</wicri:regionArea><placeName><region type="state">Bahia</region></placeName></affiliation></author><author><name sortKey="Castro, Natalia Almeida De Arnaldo Silva Rodriguez" sort="Castro, Natalia Almeida De Arnaldo Silva Rodriguez" uniqKey="Castro N" first="Natália Almeida De Arnaldo Silva Rodriguez" last="Castro">Natália Almeida De Arnaldo Silva Rodriguez Castro</name><affiliation wicri:level="2"><nlm:affiliation>Hospital da Criança, Faculdade de Medicina, São José do Rio Preto, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital da Criança, Faculdade de Medicina, São José do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Genu, Daniel Hilario Santos" sort="Genu, Daniel Hilario Santos" uniqKey="Genu D" first="Daniel Hilário Santos" last="Genu">Daniel Hilário Santos Genu</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Estadual Getúlio Vargas, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Estadual Getúlio Vargas, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Foronda, Flavia Andrea Krepel" sort="Foronda, Flavia Andrea Krepel" uniqKey="Foronda F" first="Flavia Andrea Krepel" last="Foronda">Flavia Andrea Krepel Foronda</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Sírio Libanês, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio Libanês, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Cunha, Antonio Jose Ledo A" sort="Cunha, Antonio Jose Ledo A" uniqKey="Cunha A" first="Antonio José Ledo A" last="Cunha">Antonio José Ledo A. Cunha</name><affiliation wicri:level="2"><nlm:affiliation>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Magalhaes Barbosa, Maria Clara" sort="De Magalhaes Barbosa, Maria Clara" uniqKey="De Magalhaes Barbosa M" first="Maria Clara" last="De Magalhães-Barbosa">Maria Clara De Magalhães-Barbosa</name><affiliation wicri:level="2"><nlm:affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2020">2020 Sep - Oct</date><idno type="RBID">pubmed:32781034</idno><idno type="pmid">32781034</idno><idno type="doi">10.1016/j.jped.2020.07.002</idno><idno type="pmc">PMC7402103</idno><idno type="wicri:Area/Main/Corpus">000F05</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000F05</idno><idno type="wicri:Area/Main/Curation">000F05</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000F05</idno><idno type="wicri:Area/Main/Exploration">000F05</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.</title><author><name sortKey="Prata Barbosa, Arnaldo" sort="Prata Barbosa, Arnaldo" uniqKey="Prata Barbosa A" first="Arnaldo" last="Prata-Barbosa">Arnaldo Prata-Barbosa</name><affiliation wicri:level="2"><nlm:affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil. Electronic address: arnaldo.prata@idor.org.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Lima Setta, Fernanda" sort="Lima Setta, Fernanda" uniqKey="Lima Setta F" first="Fernanda" last="Lima-Setta">Fernanda Lima-Setta</name><affiliation wicri:level="2"><nlm:affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Santos, Gustavo Rodrigues Dos" sort="Santos, Gustavo Rodrigues Dos" uniqKey="Santos G" first="Gustavo Rodrigues Dos" last="Santos">Gustavo Rodrigues Dos Santos</name><affiliation wicri:level="2"><nlm:affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Lanziotti, Vanessa Soares" sort="Lanziotti, Vanessa Soares" uniqKey="Lanziotti V" first="Vanessa Soares" last="Lanziotti">Vanessa Soares Lanziotti</name><affiliation wicri:level="2"><nlm:affiliation>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Castro, Roberta Esteves Vieira" sort="De Castro, Roberta Esteves Vieira" uniqKey="De Castro R" first="Roberta Esteves Vieira" last="De Castro">Roberta Esteves Vieira De Castro</name><affiliation wicri:level="2"><nlm:affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Souza, Daniela Carla" sort="De Souza, Daniela Carla" uniqKey="De Souza D" first="Daniela Carla" last="De Souza">Daniela Carla De Souza</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Sírio Libanês, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio Libanês, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Raymundo, Carlos Eduardo" sort="Raymundo, Carlos Eduardo" uniqKey="Raymundo C" first="Carlos Eduardo" last="Raymundo">Carlos Eduardo Raymundo</name><affiliation wicri:level="2"><nlm:affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Oliveira, Felipe Rezende Caino" sort="De Oliveira, Felipe Rezende Caino" uniqKey="De Oliveira F" first="Felipe Rezende Caino" last="De Oliveira">Felipe Rezende Caino De Oliveira</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Alvorada Moema, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Alvorada Moema, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="De Lima, Lucio Flavio Peixoto" sort="De Lima, Lucio Flavio Peixoto" uniqKey="De Lima L" first="Lucio Flavio Peixoto" last="De Lima">Lucio Flavio Peixoto De Lima</name><affiliation wicri:level="2"><nlm:affiliation>Hospital SEPACO, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital SEPACO, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Tonial, Cristian Tedesco" sort="Tonial, Cristian Tedesco" uniqKey="Tonial C" first="Cristian Tedesco" last="Tonial">Cristian Tedesco Tonial</name><affiliation wicri:level="2"><nlm:affiliation>Pontifícia Universidade Católica (PUC-RS), Porto Alegre, RS, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Pontifícia Universidade Católica (PUC-RS), Porto Alegre, RS</wicri:regionArea><placeName><region type="state">Rio Grande do Sul</region></placeName></affiliation></author><author><name sortKey="Colleti, Jose" sort="Colleti, Jose" uniqKey="Colleti J" first="José" last="Colleti">José Colleti</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Assunção, São Bernardo do Campo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Assunção, São Bernardo do Campo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Bellinat, Ana Paula Novaes" sort="Bellinat, Ana Paula Novaes" uniqKey="Bellinat A" first="Ana Paula Novaes" last="Bellinat">Ana Paula Novaes Bellinat</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Martagão Gesteira, Salvador, BA, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Martagão Gesteira, Salvador, BA</wicri:regionArea><placeName><region type="state">Bahia</region></placeName></affiliation></author><author><name sortKey="Lorenzo, Vivian Botelho" sort="Lorenzo, Vivian Botelho" uniqKey="Lorenzo V" first="Vivian Botelho" last="Lorenzo">Vivian Botelho Lorenzo</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Couto Maia, Salvador, BA, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Couto Maia, Salvador, BA</wicri:regionArea><placeName><region type="state">Bahia</region></placeName></affiliation></author><author><name sortKey="Zeitel, Raquel De Seixas" sort="Zeitel, Raquel De Seixas" uniqKey="Zeitel R" first="Raquel De Seixas" last="Zeitel">Raquel De Seixas Zeitel</name><affiliation wicri:level="2"><nlm:affiliation>Universidade do Estado do Rio de Janeiro (UERJ), Hospital Pedro Ernesto, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade do Estado do Rio de Janeiro (UERJ), Hospital Pedro Ernesto, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Pulcheri, Lucas" sort="Pulcheri, Lucas" uniqKey="Pulcheri L" first="Lucas" last="Pulcheri">Lucas Pulcheri</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Rios D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Rios D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Costa, Fernanda Ciuffo Monte Da" sort="Costa, Fernanda Ciuffo Monte Da" uniqKey="Costa F" first="Fernanda Ciuffo Monte Da" last="Costa">Fernanda Ciuffo Monte Da Costa</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Quinta D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Quinta D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="La Torre, Fabiola Peixoto Ferreira" sort="La Torre, Fabiola Peixoto Ferreira" uniqKey="La Torre F" first="Fabíola Peixoto Ferreira" last="La Torre">Fabíola Peixoto Ferreira La Torre</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Sino Brasileiro, Osasco, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sino Brasileiro, Osasco, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Figueiredo, Elaine Augusta Das Neves" sort="Figueiredo, Elaine Augusta Das Neves" uniqKey="Figueiredo E" first="Elaine Augusta Das Neves" last="Figueiredo">Elaine Augusta Das Neves Figueiredo</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Pediátrico Unimed, Belém, PA, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Pediátrico Unimed, Belém, PA</wicri:regionArea><placeName><region type="state">Pará</region></placeName></affiliation></author><author><name sortKey="Silva, Thiago Peres Da" sort="Silva, Thiago Peres Da" uniqKey="Silva T" first="Thiago Peres Da" last="Silva">Thiago Peres Da Silva</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Real D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Real D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Riveiro, Paula Marins" sort="Riveiro, Paula Marins" uniqKey="Riveiro P" first="Paula Marins" last="Riveiro">Paula Marins Riveiro</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Caxias D'Or, Duque de Caxias, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Caxias D'Or, Duque de Caxias, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Mota, Isabele Coelho Fonseca Da" sort="Mota, Isabele Coelho Fonseca Da" uniqKey="Mota I" first="Isabele Coelho Fonseca Da" last="Mota">Isabele Coelho Fonseca Da Mota</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Jutta Batista, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Jutta Batista, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Brandao, Igor Bromonschenkel" sort="Brandao, Igor Bromonschenkel" uniqKey="Brandao I" first="Igor Bromonschenkel" last="Brandão">Igor Bromonschenkel Brandão</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Niteroi D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Niteroi D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Azevedo, Zina Maria Almeida" sort="De Azevedo, Zina Maria Almeida" uniqKey="De Azevedo Z" first="Zina Maria Almeida" last="De Azevedo">Zina Maria Almeida De Azevedo</name><affiliation wicri:level="2"><nlm:affiliation>Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Gregory, Simone Camera" sort="Gregory, Simone Camera" uniqKey="Gregory S" first="Simone Camera" last="Gregory">Simone Camera Gregory</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Estadual da Criança, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Estadual da Criança, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Boedo, Fernanda Raquel Oliveira" sort="Boedo, Fernanda Raquel Oliveira" uniqKey="Boedo F" first="Fernanda Raquel Oliveira" last="Boedo">Fernanda Raquel Oliveira Boedo</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Norte D'Or, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Norte D'Or, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Carvalho, Rosana Novais" sort="De Carvalho, Rosana Novais" uniqKey="De Carvalho R" first="Rosana Novais" last="De Carvalho">Rosana Novais De Carvalho</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Santa Izabel, Santa Casa da Misericórdia, Salvador, BA, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Santa Izabel, Santa Casa da Misericórdia, Salvador, BA</wicri:regionArea><placeName><region type="state">Bahia</region></placeName></affiliation></author><author><name sortKey="Castro, Natalia Almeida De Arnaldo Silva Rodriguez" sort="Castro, Natalia Almeida De Arnaldo Silva Rodriguez" uniqKey="Castro N" first="Natália Almeida De Arnaldo Silva Rodriguez" last="Castro">Natália Almeida De Arnaldo Silva Rodriguez Castro</name><affiliation wicri:level="2"><nlm:affiliation>Hospital da Criança, Faculdade de Medicina, São José do Rio Preto, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital da Criança, Faculdade de Medicina, São José do Rio Preto, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Genu, Daniel Hilario Santos" sort="Genu, Daniel Hilario Santos" uniqKey="Genu D" first="Daniel Hilário Santos" last="Genu">Daniel Hilário Santos Genu</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Estadual Getúlio Vargas, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Estadual Getúlio Vargas, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="Foronda, Flavia Andrea Krepel" sort="Foronda, Flavia Andrea Krepel" uniqKey="Foronda F" first="Flavia Andrea Krepel" last="Foronda">Flavia Andrea Krepel Foronda</name><affiliation wicri:level="2"><nlm:affiliation>Hospital Sírio Libanês, São Paulo, SP, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Hospital Sírio Libanês, São Paulo, SP</wicri:regionArea><placeName><region type="state">État de São Paulo</region></placeName></affiliation></author><author><name sortKey="Cunha, Antonio Jose Ledo A" sort="Cunha, Antonio Jose Ledo A" uniqKey="Cunha A" first="Antonio José Ledo A" last="Cunha">Antonio José Ledo A. Cunha</name><affiliation wicri:level="2"><nlm:affiliation>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author><author><name sortKey="De Magalhaes Barbosa, Maria Clara" sort="De Magalhaes Barbosa, Maria Clara" uniqKey="De Magalhaes Barbosa M" first="Maria Clara" last="De Magalhães-Barbosa">Maria Clara De Magalhães-Barbosa</name><affiliation wicri:level="2"><nlm:affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</nlm:affiliation><country xml:lang="fr">Brésil</country><wicri:regionArea>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ</wicri:regionArea><placeName><region type="state">État de Rio de Janeiro</region></placeName></affiliation></author></analytic><series><title level="j">Jornal de pediatria</title><idno type="eISSN">1678-4782</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Brazil (MeSH)</term><term>COVID-19 (MeSH)</term><term>Child (MeSH)</term><term>Child, Preschool (MeSH)</term><term>Coronavirus Infections (epidemiology)</term><term>Coronavirus Infections (therapy)</term><term>Female (MeSH)</term><term>Hospitalization (MeSH)</term><term>Humans (MeSH)</term><term>Infant (MeSH)</term><term>Infant, Newborn (MeSH)</term><term>Intensive Care Units, Pediatric (statistics & numerical data)</term><term>Length of Stay (statistics & numerical data)</term><term>Male (MeSH)</term><term>Pandemics (MeSH)</term><term>Pneumonia, Viral (epidemiology)</term><term>Pneumonia, Viral (therapy)</term><term>Prospective Studies (MeSH)</term><term>Respiration, Artificial (methods)</term><term>Respiration, Artificial (statistics & numerical data)</term><term>SARS-CoV-2 (MeSH)</term><term>Systemic Inflammatory Response Syndrome (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term><term>Betacoronavirus (MeSH)</term><term>Brésil (MeSH)</term><term>Durée du séjour (statistiques et données numériques)</term><term>Enfant (MeSH)</term><term>Enfant d'âge préscolaire (MeSH)</term><term>Femelle (MeSH)</term><term>Hospitalisation (MeSH)</term><term>Humains (MeSH)</term><term>Infections à coronavirus (thérapie)</term><term>Infections à coronavirus (épidémiologie)</term><term>Mâle (MeSH)</term><term>Nourrisson (MeSH)</term><term>Nouveau-né (MeSH)</term><term>Pandémies (MeSH)</term><term>Pneumopathie virale (thérapie)</term><term>Pneumopathie virale (épidémiologie)</term><term>Syndrome de réponse inflammatoire généralisée (MeSH)</term><term>Unités de soins intensifs pédiatriques (statistiques et données numériques)</term><term>Ventilation artificielle (méthodes)</term><term>Ventilation artificielle (statistiques et données numériques)</term><term>Études prospectives (MeSH)</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Brazil</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="méthodes" xml:lang="fr"><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Intensive Care Units, Pediatric</term><term>Length of Stay</term><term>Respiration, Artificial</term></keywords><keywords scheme="MESH" qualifier="statistiques et données numériques" xml:lang="fr"><term>Durée du séjour</term><term>Unités de soins intensifs pédiatriques</term><term>Ventilation artificielle</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Pneumonia, Viral</term></keywords><keywords scheme="MESH" qualifier="thérapie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Infections à coronavirus</term><term>Pneumopathie virale</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Betacoronavirus</term><term>COVID-19</term><term>Child</term><term>Child, Preschool</term><term>Female</term><term>Hospitalization</term><term>Humans</term><term>Infant</term><term>Infant, Newborn</term><term>Male</term><term>Pandemics</term><term>Prospective Studies</term><term>SARS-CoV-2</term><term>Systemic Inflammatory Response Syndrome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Betacoronavirus</term><term>Brésil</term><term>Enfant</term><term>Enfant d'âge préscolaire</term><term>Femelle</term><term>Hospitalisation</term><term>Humains</term><term>Mâle</term><term>Nourrisson</term><term>Nouveau-né</term><term>Pandémies</term><term>Syndrome de réponse inflammatoire généralisée</term><term>Études prospectives</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Brésil</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>OBJECTIVE</b></p><p>To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19.</p></div><div type="abstract" xml:lang="en"><p><b>METHOD</b></p><p>Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity.</p></div><div type="abstract" xml:lang="en"><p><b>RESULTS</b></p><p>Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43-21.12; p = 0.01).</p></div><div type="abstract" xml:lang="en"><p><b>CONCLUSIONS</b></p><p>In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.</p></div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Curated" Owner="NLM"><PMID Version="1">32781034</PMID><DateCompleted><Year>2020</Year><Month>10</Month><Day>22</Day></DateCompleted><DateRevised><Year>2021</Year><Month>01</Month><Day>10</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1678-4782</ISSN><JournalIssue CitedMedium="Internet"><Volume>96</Volume><Issue>5</Issue><PubDate><MedlineDate>2020 Sep - Oct</MedlineDate></PubDate></JournalIssue><Title>Jornal de pediatria</Title><ISOAbbreviation>J Pediatr (Rio J)</ISOAbbreviation></Journal><ArticleTitle>Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.</ArticleTitle><Pagination><MedlinePgn>582-592</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0021-7557(20)30192-3</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.jped.2020.07.002</ELocationID><Abstract><AbstractText Label="OBJECTIVE">To describe the clinical characteristics of children and adolescents admitted to intensive care with confirmed COVID-19.</AbstractText><AbstractText Label="METHOD">Prospective, multicenter, observational study, in 19 pediatric intensive care units. Patients aged 1 month to 19 years admitted consecutively (March-May 2020) were included. Demographic, clinical-epidemiological features, treatment, and outcomes were collected. Subgroups were compared according to comorbidities, age < 1 year, and need for invasive mechanical ventilation. A multivariable logistic regression model was used for predictors of severity.</AbstractText><AbstractText Label="RESULTS">Seventy-nine patients were included (ten with multisystemic inflammatory syndrome). Median age 4 years; 54% male (multisystemic inflammatory syndrome, 80%); 41% had comorbidities (multisystemic inflammatory syndrome, 20%). Fever (76%), cough (51%), and tachypnea (50%) were common in both groups. Severe symptoms, gastrointestinal symptoms, and higher inflammatory markers were more frequent in multisystemic inflammatory syndrome. Interstitial lung infiltrates were common in both groups, but pleural effusion was more prevalent in the multisystemic inflammatory syndrome group (43% vs. 14%). Invasive mechanical ventilation was used in 18% (median 7.5 days); antibiotics, oseltamivir, and corticosteroids were used in 76%, 43%, and 23%, respectively, but not hydroxychloroquine. The median pediatric intensive care unit length-of-stay was five days; there were two deaths (3%) in the non- multisystemic inflammatory syndrome group. Patients with comorbidities were older and comorbidities were independently associated with the need for invasive mechanical ventilation (OR 5.5; 95% CI, 1.43-21.12; p = 0.01).</AbstractText><AbstractText Label="CONCLUSIONS">In Brazilian pediatric intensive care units, COVID-19 had low mortality, age less than 1 year was not associated with a worse prognosis, and patients with multisystemic inflammatory syndrome had more severe symptoms, higher inflammatory biomarkers, and a greater predominance of males, but only comorbidities and chronic diseases were independent predictors of severity.</AbstractText><CopyrightInformation>Copyright © 2020 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Prata-Barbosa</LastName><ForeName>Arnaldo</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil. Electronic address: arnaldo.prata@idor.org.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lima-Setta</LastName><ForeName>Fernanda</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Santos</LastName><ForeName>Gustavo Rodrigues Dos</ForeName><Initials>GRD</Initials><AffiliationInfo><Affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lanziotti</LastName><ForeName>Vanessa Soares</ForeName><Initials>VS</Initials><AffiliationInfo><Affiliation>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Castro</LastName><ForeName>Roberta Esteves Vieira</ForeName><Initials>REV</Initials><AffiliationInfo><Affiliation>Universidade do Estado do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Souza</LastName><ForeName>Daniela Carla</ForeName><Initials>DC</Initials><AffiliationInfo><Affiliation>Hospital Sírio Libanês, São Paulo, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Raymundo</LastName><ForeName>Carlos Eduardo</ForeName><Initials>CE</Initials><AffiliationInfo><Affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Oliveira</LastName><ForeName>Felipe Rezende Caino</ForeName><Initials>FRC</Initials><AffiliationInfo><Affiliation>Hospital Alvorada Moema, São Paulo, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Lima</LastName><ForeName>Lucio Flavio Peixoto</ForeName><Initials>LFP</Initials><AffiliationInfo><Affiliation>Hospital SEPACO, São Paulo, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tonial</LastName><ForeName>Cristian Tedesco</ForeName><Initials>CT</Initials><AffiliationInfo><Affiliation>Pontifícia Universidade Católica (PUC-RS), Porto Alegre, RS, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Colleti</LastName><ForeName>José</ForeName><Initials>J</Initials><Suffix>Jr</Suffix><AffiliationInfo><Affiliation>Hospital Assunção, São Bernardo do Campo, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bellinat</LastName><ForeName>Ana Paula Novaes</ForeName><Initials>APN</Initials><AffiliationInfo><Affiliation>Hospital Martagão Gesteira, Salvador, BA, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lorenzo</LastName><ForeName>Vivian Botelho</ForeName><Initials>VB</Initials><AffiliationInfo><Affiliation>Hospital Couto Maia, Salvador, BA, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zeitel</LastName><ForeName>Raquel de Seixas</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Universidade do Estado do Rio de Janeiro (UERJ), Hospital Pedro Ernesto, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pulcheri</LastName><ForeName>Lucas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hospital Rios D'Or, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Costa</LastName><ForeName>Fernanda Ciuffo Monte da</ForeName><Initials>FCMD</Initials><AffiliationInfo><Affiliation>Hospital Quinta D'Or, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>La Torre</LastName><ForeName>Fabíola Peixoto Ferreira</ForeName><Initials>FPF</Initials><AffiliationInfo><Affiliation>Hospital Sino Brasileiro, Osasco, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figueiredo</LastName><ForeName>Elaine Augusta das Neves</ForeName><Initials>EADN</Initials><AffiliationInfo><Affiliation>Hospital Pediátrico Unimed, Belém, PA, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Silva</LastName><ForeName>Thiago Peres da</ForeName><Initials>TPD</Initials><AffiliationInfo><Affiliation>Hospital Real D'Or, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Riveiro</LastName><ForeName>Paula Marins</ForeName><Initials>PM</Initials><AffiliationInfo><Affiliation>Hospital Caxias D'Or, Duque de Caxias, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mota</LastName><ForeName>Isabele Coelho Fonseca da</ForeName><Initials>ICFD</Initials><AffiliationInfo><Affiliation>Hospital Jutta Batista, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brandão</LastName><ForeName>Igor Bromonschenkel</ForeName><Initials>IB</Initials><AffiliationInfo><Affiliation>Hospital Niteroi D'Or, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Azevedo</LastName><ForeName>Zina Maria Almeida</ForeName><Initials>ZMA</Initials><AffiliationInfo><Affiliation>Instituto Fernandes Figueira, Fiocruz, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Gregory</LastName><ForeName>Simone Camera</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Hospital Estadual da Criança, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Boedo</LastName><ForeName>Fernanda Raquel Oliveira</ForeName><Initials>FRO</Initials><AffiliationInfo><Affiliation>Hospital Norte D'Or, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Carvalho</LastName><ForeName>Rosana Novais</ForeName><Initials>RN</Initials><AffiliationInfo><Affiliation>Hospital Santa Izabel, Santa Casa da Misericórdia, Salvador, BA, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castro</LastName><ForeName>Natália Almeida de Arnaldo Silva Rodriguez</ForeName><Initials>NAASR</Initials><AffiliationInfo><Affiliation>Hospital da Criança, Faculdade de Medicina, São José do Rio Preto, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Genu</LastName><ForeName>Daniel Hilário Santos</ForeName><Initials>DHS</Initials><AffiliationInfo><Affiliation>Hospital Estadual Getúlio Vargas, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Foronda</LastName><ForeName>Flavia Andrea Krepel</ForeName><Initials>FAK</Initials><AffiliationInfo><Affiliation>Hospital Sírio Libanês, São Paulo, SP, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cunha</LastName><ForeName>Antonio José Ledo A</ForeName><Initials>AJLA</Initials><AffiliationInfo><Affiliation>Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>de Magalhães-Barbosa</LastName><ForeName>Maria Clara</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Instituto D'Or de Pesquisa e Ensino (IDOR), Rio de Janeiro, RJ, Brazil.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><CollectiveName>Brazilian Research Network in Pediatric Intensive Care, (BRnet-PIC)</CollectiveName><AffiliationInfo><Affiliation>Brazilian Research Network in Pediatric Intensive Care (BRnet-PIC), Brazil.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>08</Month><Day>04</Day></ArticleDate></Article><MedlineJournalInfo><Country>Brazil</Country><MedlineTA>J Pediatr (Rio J)</MedlineTA><NlmUniqueID>2985188R</NlmUniqueID><ISSNLinking>0021-7557</ISSNLinking></MedlineJournalInfo><SupplMeshList><SupplMeshName Type="Disease" UI="C000705967">pediatric multisystem inflammatory disease, COVID-19 related</SupplMeshName></SupplMeshList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000073640" MajorTopicYN="N">Betacoronavirus</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001938" MajorTopicYN="N" Type="Geographic">Brazil</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000086382" MajorTopicYN="N">COVID-19</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002648" MajorTopicYN="N">Child</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002675" MajorTopicYN="N">Child, Preschool</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018352" MajorTopicYN="N">Coronavirus Infections</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006760" MajorTopicYN="N">Hospitalization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007223" MajorTopicYN="N">Infant</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007231" MajorTopicYN="N">Infant, Newborn</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015278" MajorTopicYN="N">Intensive Care Units, Pediatric</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="Y">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007902" MajorTopicYN="N">Length of Stay</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D058873" MajorTopicYN="Y">Pandemics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011024" MajorTopicYN="N">Pneumonia, Viral</DescriptorName><QualifierName UI="Q000453" MajorTopicYN="N">epidemiology</QualifierName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011446" MajorTopicYN="N">Prospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012121" MajorTopicYN="N">Respiration, Artificial</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000086402" MajorTopicYN="N">SARS-CoV-2</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018746" MajorTopicYN="Y">Systemic Inflammatory Response Syndrome</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">Brasil</Keyword><Keyword MajorTopicYN="Y">Brazil</Keyword><Keyword MajorTopicYN="Y">COVID-19</Keyword><Keyword MajorTopicYN="Y">Pediatria</Keyword><Keyword MajorTopicYN="Y">Pediatric intensive care</Keyword><Keyword MajorTopicYN="Y">Pediatrics</Keyword><Keyword MajorTopicYN="Y">SARS-CoV-2</Keyword><Keyword MajorTopicYN="Y">Terapia intensiva pediátrica</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>07</Month><Day>16</Day></PubMedPubDate><PubMedPubDate 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Bromonschenkel" uniqKey="Brandao I" first="Igor Bromonschenkel" last="Brandão">Igor Bromonschenkel Brandão</name><name sortKey="Castro, Natalia Almeida De Arnaldo Silva Rodriguez" sort="Castro, Natalia Almeida De Arnaldo Silva Rodriguez" uniqKey="Castro N" first="Natália Almeida De Arnaldo Silva Rodriguez" last="Castro">Natália Almeida De Arnaldo Silva Rodriguez Castro</name><name sortKey="Colleti, Jose" sort="Colleti, Jose" uniqKey="Colleti J" first="José" last="Colleti">José Colleti</name><name sortKey="Costa, Fernanda Ciuffo Monte Da" sort="Costa, Fernanda Ciuffo Monte Da" uniqKey="Costa F" first="Fernanda Ciuffo Monte Da" last="Costa">Fernanda Ciuffo Monte Da Costa</name><name sortKey="Cunha, Antonio Jose Ledo A" sort="Cunha, Antonio Jose Ledo A" uniqKey="Cunha A" first="Antonio José Ledo A" last="Cunha">Antonio José Ledo A. Cunha</name><name sortKey="De Azevedo, Zina Maria Almeida" sort="De Azevedo, Zina Maria Almeida" uniqKey="De Azevedo Z" first="Zina Maria Almeida" last="De Azevedo">Zina Maria Almeida De Azevedo</name><name sortKey="De Carvalho, Rosana Novais" sort="De Carvalho, Rosana Novais" uniqKey="De Carvalho R" first="Rosana Novais" last="De Carvalho">Rosana Novais De Carvalho</name><name sortKey="De Castro, Roberta Esteves Vieira" sort="De Castro, Roberta Esteves Vieira" uniqKey="De Castro R" first="Roberta Esteves Vieira" last="De Castro">Roberta Esteves Vieira De Castro</name><name sortKey="De Lima, Lucio Flavio Peixoto" sort="De Lima, Lucio Flavio Peixoto" uniqKey="De Lima L" first="Lucio Flavio Peixoto" last="De Lima">Lucio Flavio Peixoto De Lima</name><name sortKey="De Magalhaes Barbosa, Maria Clara" sort="De Magalhaes Barbosa, Maria Clara" uniqKey="De Magalhaes Barbosa M" first="Maria Clara" last="De Magalhães-Barbosa">Maria Clara De Magalhães-Barbosa</name><name sortKey="De Oliveira, Felipe Rezende Caino" sort="De Oliveira, Felipe Rezende Caino" uniqKey="De Oliveira F" first="Felipe Rezende Caino" last="De Oliveira">Felipe Rezende Caino De Oliveira</name><name sortKey="De Souza, Daniela Carla" sort="De Souza, Daniela Carla" uniqKey="De Souza D" first="Daniela Carla" last="De Souza">Daniela Carla De Souza</name><name sortKey="Figueiredo, Elaine Augusta Das Neves" sort="Figueiredo, Elaine Augusta Das Neves" uniqKey="Figueiredo E" first="Elaine Augusta Das Neves" last="Figueiredo">Elaine Augusta Das Neves Figueiredo</name><name sortKey="Foronda, Flavia Andrea Krepel" sort="Foronda, Flavia Andrea Krepel" uniqKey="Foronda F" first="Flavia Andrea Krepel" last="Foronda">Flavia Andrea Krepel Foronda</name><name sortKey="Genu, Daniel Hilario Santos" sort="Genu, Daniel Hilario Santos" uniqKey="Genu D" first="Daniel Hilário Santos" last="Genu">Daniel Hilário Santos Genu</name><name sortKey="Gregory, Simone Camera" sort="Gregory, Simone Camera" uniqKey="Gregory S" first="Simone Camera" last="Gregory">Simone Camera Gregory</name><name sortKey="La Torre, Fabiola Peixoto Ferreira" sort="La Torre, Fabiola Peixoto Ferreira" uniqKey="La Torre F" first="Fabíola Peixoto Ferreira" last="La Torre">Fabíola Peixoto Ferreira La Torre</name><name sortKey="Lanziotti, Vanessa Soares" sort="Lanziotti, Vanessa Soares" uniqKey="Lanziotti V" first="Vanessa Soares" last="Lanziotti">Vanessa Soares Lanziotti</name><name sortKey="Lima Setta, Fernanda" sort="Lima Setta, Fernanda" uniqKey="Lima Setta F" first="Fernanda" last="Lima-Setta">Fernanda Lima-Setta</name><name sortKey="Lorenzo, Vivian Botelho" sort="Lorenzo, Vivian Botelho" uniqKey="Lorenzo V" first="Vivian Botelho" last="Lorenzo">Vivian Botelho Lorenzo</name><name sortKey="Mota, Isabele Coelho Fonseca Da" sort="Mota, Isabele Coelho Fonseca Da" uniqKey="Mota I" first="Isabele Coelho Fonseca Da" last="Mota">Isabele Coelho Fonseca Da Mota</name><name sortKey="Pulcheri, Lucas" sort="Pulcheri, Lucas" uniqKey="Pulcheri L" first="Lucas" last="Pulcheri">Lucas Pulcheri</name><name sortKey="Raymundo, Carlos Eduardo" sort="Raymundo, Carlos Eduardo" uniqKey="Raymundo C" first="Carlos Eduardo" last="Raymundo">Carlos Eduardo Raymundo</name><name sortKey="Riveiro, Paula Marins" sort="Riveiro, Paula Marins" uniqKey="Riveiro P" first="Paula Marins" last="Riveiro">Paula Marins Riveiro</name><name sortKey="Santos, Gustavo Rodrigues Dos" sort="Santos, Gustavo Rodrigues Dos" uniqKey="Santos G" first="Gustavo Rodrigues Dos" last="Santos">Gustavo Rodrigues Dos Santos</name><name sortKey="Silva, Thiago Peres Da" sort="Silva, Thiago Peres Da" uniqKey="Silva T" first="Thiago Peres Da" last="Silva">Thiago Peres Da Silva</name><name sortKey="Tonial, Cristian Tedesco" sort="Tonial, Cristian Tedesco" uniqKey="Tonial C" first="Cristian Tedesco" last="Tonial">Cristian Tedesco Tonial</name><name sortKey="Zeitel, Raquel De Seixas" sort="Zeitel, Raquel De Seixas" uniqKey="Zeitel R" first="Raquel De Seixas" last="Zeitel">Raquel De Seixas Zeitel</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= Pediatric patients with COVID-19 admitted to intensive care units in Brazil: a prospective multicenter study.
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